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Vatinoxan

CAT: 0804-HY-19057Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19057Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vatinoxan (MK-467) is an alpha 2-adrenergic receptor antagonist. The peripheral selectivity of Vatinoxan determines that it has limited penetration across the blood-brain barrier and therefore has low concentrations in the central nervous system. Vatinoxan antagonizes alpha 2-adrenergic receptor receptors by binding to them, thereby reducing or preventing cardiovascular effects caused by α2-adrenergic agonists. Vatinoxan can be used in studies of cardiovascular effects, sedation and analgesia[1].
CAS Number
114914-42-0
Product Name Alternative
MK-467; L-659066
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vatinoxan.html
Smiles
CS(=O)(NCCN([C@]1(CN2)CCN3CCC4=C(OC5=CC=CC=C54)[C@]3([H])C1)C2=O)=O
Molecular Formula
C20H26N4O4S
Molecular Weight
418.51
References & Citations
[1]Honkavaara J M, et al. Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs[J]. Veterinary anaesthesia and analgesia, 2020, 47 (1) : 47-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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GTR19196205-01Vatinoxan
GTR19205357-01Vatinoxan hydrochloride

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