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LUF6283

CAT: 0804-HY-100976-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100976-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LUF6283 is a potent and orally active HCA (2) partial agonist, with a Ki of 0.55 µM. LUF6283 can achieve the beneficial lipid lowering effect of niacin without producing the unwanted cutaneous flushing side effect[1].
CAS Number
92933-48-7
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Hydroxycarboxylic Acid Receptor (HCAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/luf6283.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NNC(CCCC)=C1)O
Molecular Formula
C8H12N2O2
Molecular Weight
168.20
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Li Z, et al. Effects of pyrazole partial agonists on HCA (2) -mediated flushing and VLDL-triglyceride levels in mice. Br J Pharmacol. 2012 Oct;167 (4) :818-25.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

5-Butyl-1H-pyrazole-3-carboxylic acid
CAS Number92933-48-7
PubChem CID6485181
IUPAC Name5-butyl-1H-pyrazole-3-carboxylic acid
Molecular FormulaC8H12N2O2
Molecular Weight168.19
XLogP1.8
Topological Polar Surface Area66
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count12
Formal Charge0
Complexity161
SMILES
CCCCC1=CC(=NN1)C(=O)O
InChI
InChI=1S/C8H12N2O2/c1-2-3-4-6-5-7(8(11)12)10-9-6/h5H,2-4H2,1H3,(H,9,10)(H,11,12)
InChIKey
ZJTXSGLJNBAMJS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-Butyl-1H-pyrazole-3-carboxylic acid
CAS: 92933-48-7
CID: 6485181
Formula: C8H12N2O2
MW: 168.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight168.19
XLogP31.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass168.089877630
Monoisotopic Mass168.089877630
Topological Polar Surface Area66 Ų
Heavy Atom Count12
Formal Charge0
Complexity161
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
471016LUF6283

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