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Halenaquinone

CAT: 0804-HY-111266Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111266Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Halenaquinone is a phosphatidylinositol 3-kinase inhibitor and can be isolated from the marine sponge Petrosia alfiani. Halenaquinone inhibits RANKL-induced osteoclastogenesis, and induces cell apoptosis in PC12 cells[1][2][3].
CAS Number
86690-14-4
UNSPSC
12352005
Target
Apoptosis; PI3K
Type
Natural Products
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/halenaquinone.html
Smiles
O=C1CC[C@@](C2=C3OC=C21)(C)C4=C(C3=O)C=C(C(C=CC5=O)=O)C5=C4
Molecular Formula
C20H12O5
Molecular Weight
332.31
References & Citations
[1]Deborah M. Roll, et al. Halenaquinone, a pentacyclic polyketide from a marine sponge. : Journal of the American Chemical Society.Vol 105/Issue 19.|[2]Fujiwara H, et al. Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells. Eur J Pharmacol. 2001;413 (1) :37-45. |[3]Tsukamoto S, et al. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Bioorg Med Chem Lett. 2014;24 (22) :5315-5317.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
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