IGF-I Receptor β (phospho-Tyr1135) rabbit pAb
CAT:
855-ES15515-01
Size:
50 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
IGF-I Receptor β (phospho-Tyr1135) rabbit pAb
- Description: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],
- Synonyms: Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
- Gene ID: 3480
- UniProt: P08069
- Cellular Locus: Cell membrane ; Single-pass type I membrane protein.
- Host: Rabbit
- Species Reactivity: Human, Mouse
- Immunogen: Synthesized phosho peptide around human IGF-I Receptor β (Tyr1135)
- Clonality: Polyclonal
- Validated Applications: WB
- Stability: 1 year
- Concentration: 1 mg/mL
- Dilution: WB 1:1000-2000
- Molecular Weight: pro: 155kD, recetor beta: 95kD
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.