(±)-Huperzine A

• CAS Number: 120786-18-7
• UNSPSC Description: (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease.
• Target Antigen: Cholinesterase (ChE)
• Type: Natural Products
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/__plusmn__-huperzine-a.html
• Solubility: DMSO : ≥ 50 mg/mL
• Smiles: O=C1C=CC(C(/C2=C/C)(N)CC(C)=CC2C3)=C3N1
• Molecular Weight: 242.322
• References & Citations: [1]Wang J, et al. Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. J Neurosci Res. 2010 Mar;88(4):807-15.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported