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Pentabromopseudilin

CAT: 0804-HY-113604-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113604-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa) . PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer[1].
CAS Number
10245-81-5
Product Name Alternative
AZD0865
UNSPSC
12352005
Target
Antibiotic; TGF-β Receptor
Type
Reference compound
Related Pathways
Anti-infection; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pentabromopseudilin.html
Purity
99.63
Solubility
DMSO : ≥ 125 mg/mL
Smiles
OC1=C(C2=C(Br)C(Br)=C(Br)N2)C=C(Br)C=C1Br
Molecular Formula
C10H4Br5NO
Molecular Weight
553.66
References & Citations
[1]Shih-Wei W, et al. Pentabromopseudilin: a myosin V inhibitor suppresses TGF-β activity by recruiting the type II TGF-β receptor to lysosomal degradation. J Enzyme Inhib Med Chem. 2018;33 (1) :920-935.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
KAA24581-01Pentabromopseudilin

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