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L 731734

CAT: 0804-HY-114840Size: 1 EachDry Ice: NoHazardous: No
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Description
L 731734 is a prodrug of L-731735 , and inhibits Ras processing in cells transformed with v-ras[1].
CAS Number
149786-89-0
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-731734.html
Smiles
O=C1[C@H](CCO1)NC([C@H]([C@@H](C)CC)NC[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)=O
Molecular Formula
C19H38N4O3S
Molecular Weight
402.60
References & Citations
[1]Kohl NE, et al. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science. 1993;260 (5116) :1934-1937.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

L 731734

structure given in first source; an inhibitor of farnesyltransferase; a prodrug of L 731735

CAS Number149786-89-0
PubChem CID44153693
IUPAC Name2-[[2-[(2-amino-3-sulfanylpropyl)amino]-3-methylpentyl]amino]-3-methyl-N-(2-oxooxolan-3-yl)pentanamide
Molecular FormulaC19H38N4O3S
Molecular Weight402.6
XLogP1.7
Topological Polar Surface Area106
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count13
Heavy Atom Count27
Formal Charge0
Complexity466
SMILES
CCC(C)C(CNC(C(C)CC)C(=O)NC1CCOC1=O)NCC(CS)N
InChI
InChI=1S/C19H38N4O3S/c1-5-12(3)16(21-9-14(20)11-27)10-22-17(13(4)6-2)18(24)23-15-7-8-26-19(15)25/h12-17,21-22,27H,5-11,20H2,1-4H3,(H,23,24)
InChIKey
SSUQYMRCKYEGEO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of L 731734
CAS: 149786-89-0
CID: 44153693
Formula: C19H38N4O3S
MW: 402.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight402.6
XLogP31.7
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count13
Exact Mass402.26646226
Monoisotopic Mass402.26646226
Topological Polar Surface Area106 Ų
Heavy Atom Count27
Formal Charge0
Complexity466
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count6
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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