Neramexane (mesylate)

• Description :

  Neramexane mesylate is an α9α10 cholinergic nicotinic receptors and N-methyl-D-aspartate receptors (NMDA) antagonist. Neramexane mesylate can improve moderate to severe tinnitus, and also shows neuroprotective effects[1][1].

• UNSPSC :

  12352211

• Target :

  IGluR; nAChR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/neramexane-mesylate.html

• Smiles :

  NC1(CC(C)(CC(C)(C1)C)C)C.CS(=O)(O)=O

• Molecular Formula :

  C12H27NO3S

• Molecular Weight :

  265.41

• References & Citations :

  [1]Suckfüll M, et al. A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of neramexane in patients with moderate to severe subjective tinnitus. BMC Ear Nose Throat Disord. 2011;11:1. Published 2011 Jan 11. |[2]Sukhotina IA, et al. Caffeine withdrawal syndrome in social interaction test in mice: effects of the NMDA receptor channel blockers, memantine and neramexane. Behav Pharmacol. 2004;15 (3) :207-214.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• CAS Number :

  [457068-92-7]