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Larazotide

CAT: 0804-HY-106268-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106268-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection[1][2].
CAS Number
258818-34-7
UNSPSC
12352209
Target
Gap Junction Protein
Type
Peptides
Related Pathways
Cytoskeleton
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/larazotide.html
Purity
99.26
Solubility
H2O : 2.5 mg/mL (ultrasonic)
Smiles
NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C32H55N9O10
Molecular Weight
725.83
References & Citations
[1]Di Micco S, et al. Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. Int J Mol Sci. 2021 Aug 30;22 (17) :9427.|[2]Gopalakrishnan S, et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35 (1) :86-94.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Phase 3
Citation 01
JID Innov. 2025 Apr 3;5 (4) :100369.|EBioMedicine. 2021 Nov:73:103641.|J Dent Res. 2023 Jan;102 (1) :82-92.|Nat Commun. 2020 Jun 19;11 (1) :3151.

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