2-Thiothymidine

• Description:

  2-Thiothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H320, H335

• Target:

  Nucleoside Antimetabolite/Analog

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/2-thiothymidine.html

• Purity:

  99.75

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O[C@H]1C[C@H](N2C(NC(C(C)=C2)=O)=S)O[C@@H]1CO

• Molecular Formula:

  C10H14N2O4S

• Molecular Weight:

  258.29

• Precautions:

  H302, H315, H320, H335

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  28585-51-5