BMS-962212

BMS-962212

• Product Name Alternative: YL0919
• CAS Number: 1430114-34-3
• UNSPSC Description: BMS-962212 is a direct, reversible, selective factor XIa (FXIa) inhibitor . BMS-962212 is well tolerated, with fast onset of pharmacodynamic (PD) responses and rapid elimination. BMS-962212 increases exposure dependently in activated partial thromboplastin time, and decreases exposure dependently in FXI clotting activity[1].
• Target Antigen: Factor Xa
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/bms-962212.html
• Purity: 99.33
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: ClC1=C(F)C(/C=C/C(N2[C@H](C(NC3=CC=C(C(O)=O)C=C3)=O)C(C=CC=C4N5C(CN(C)CC5)=O)=C4CC2)=O)=C(N6C=NN=N6)C=C1
• Molecular Weight: 659.07
• References & Citations: [1]Perera V, et al. First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects. Br J Clin Pharmacol. 2018 May;84(5):876-887.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Phase 1