VER-155008

VER-155008

• CAS Number: 1134156-31-2
• UNSPSC Description: VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.
• Target Antigen: Autophagy; HSP
• Type: Reference compound
• Related Pathways: Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/VER-155008.html
• Purity: 99.91
• Solubility: DMSO : ≥ 37 mg/mL
• Smiles: NC1=C2N=C(NCC3=CC=C(Cl)C(Cl)=C3)N([C@@H]([C@H](O)[C@@H]4O)O[C@@H]4COCC5=CC=C(C#N)C=C5)C2=NC=N1
• Molecular Weight: 556.40
• References & Citations: [1]Massey AJ, et al. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45.|[2]Yang X, et al. Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2018 Jan 30;9:48.|[3]Kita K, et al. Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells. Cancer Sci. 2017 Sep;108(9):1820-1827.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported