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Glaucocalyxin A

CAT: 0804-HY-N2112-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N2112-01Size:5 mg
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Description
Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect[1].
CAS Number
[79498-31-0]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Akt; Apoptosis; PI3K
Type
Natural Products
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/glaucocalyxin-a.html
Purity
99.41
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC1(C)C(CC[C@@]2(C)[C@@]3([H])[C@@]4(C(C([C@H](CC3)[C@H]4O)=C)=O)[C@H](O)C[C@]12[H])=O
Molecular Formula
C20H28O4
Molecular Weight
332.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhu J, et al. Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nucleartranslocation via regulating PI3K/Akt pathway. Cell Death Dis. 2018 Jun 13;9 (6) :708.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PI3K

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