Glaucocalyxin A

• Description:

  Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect[1].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Akt; Apoptosis; PI3K

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/glaucocalyxin-a.html

• Purity:

  99.41

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CC1(C)C(CC[C@@]2(C)[C@@]3([H])[C@@]4(C(C([C@H](CC3)[C@H]4O)=C)=O)[C@H](O)C[C@]12[H])=O

• Molecular Formula:

  C20H28O4

• Molecular Weight:

  332.43

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Zhu J, et al. Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nucleartranslocation via regulating PI3K/Akt pathway. Cell Death Dis. 2018 Jun 13;9 (6) :708.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  PI3K

• CAS Number:

  [79498-31-0]