2-(2,6-Dioxopiperidin-3-yl)phthalimidine

CAT:

804-HY-138793-05

Size:

10 mM / 1 mL

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CAS Number: 26581-81-7
UNSPSC Description: 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas[1][2].
Target Antigen: TNF Receptor
Type: Reference compound
Related Pathways: Apoptosis
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/2-2-6-dioxopiperidin-3-yl-phthalimidine.html
Smiles: O=C(C(N(CC1=C2C=CC=C1)C2=O)CC3)NC3=O
Molecular Weight: 244.25
References & Citations: [1]Merker HJ, et al. Embryotoxic effects of thalidomide-derivatives in the non-human primate Callithrix jacchus. I. Effects of 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine (EM12) on skeletal development. Arch Toxicol. 1988;61(3):165-179.|[2]Gershbein LL. The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas. Cancer Lett. 1991;60(2):129-133.
Shipping Conditions: Room Temperature

Cat	Name
HY-138793-03	2-(2,6-Dioxopiperidin-3-yl)phthalimidine
HY-138793-02	2-(2,6-Dioxopiperidin-3-yl)phthalimidine
HY-138793-05	2-(2,6-Dioxopiperidin-3-yl)phthalimidine
HY-138793-04	2-(2,6-Dioxopiperidin-3-yl)phthalimidine
HY-138793-01	2-(2,6-Dioxopiperidin-3-yl)phthalimidine
HY-132939	2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br
HY-49395A-04	(S)-4-(4-((4-(4-((2,6-Dioxopiperidin-3-yl)carbamoyl)-3-fluorophenyl)piperazin-1-yl)methyl)piperidin-1-yl)benzoic acid hydrochloride
HY-49395A-02	(S)-4-(4-((4-(4-((2,6-Dioxopiperidin-3-yl)carbamoyl)-3-fluorophenyl)piperazin-1-yl)methyl)piperidin-1-yl)benzoic acid hydrochloride
HY-49395A-01	(S)-4-(4-((4-(4-((2,6-Dioxopiperidin-3-yl)carbamoyl)-3-fluorophenyl)piperazin-1-yl)methyl)piperidin-1-yl)benzoic acid hydrochloride
HY-49395A-05	(S)-4-(4-((4-(4-((2,6-Dioxopiperidin-3-yl)carbamoyl)-3-fluorophenyl)piperazin-1-yl)methyl)piperidin-1-yl)benzoic acid hydrochloride

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