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LE01

CAT: 0804-HY-168285Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168285Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LE01 is a drug-linker conjugate for ADC. LE01 contains a ADC linker and a DNA topoisomerase I inhibitor DXd. LE01 can be used to synthesize HER2-targeting ADC (HER2-LE01).
CAS Number
2718125-83-6
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; Topoisomerase
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/le01.html
Smiles
O=C(C=C1)N(CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCCN(C)C(OCC(N[C@H]3CCC4=C5C3=C6C(C(N7C6)=CC([C@@](O)(CC)C(OC8)=O)=C8C7=O)=NC5=CC(F)=C4C)=O)=O)=O)=O)=O)=O)=O)C1=O
Molecular Formula
C55H61FN10O14
Molecular Weight
1105.13
References & Citations
[1]Yifan Zhang, et al. Evaluation of Double Self-Immolative Linker-Based Antibody-Drug Conjugate FDA022-BB05 with Enhanced Therapeutic Potential. J Med Chem. 2024 Nov 14;67 (21) :19852-19873.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Camptothecins; Topo I

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