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MLKL Rabbit mAb [KD Validated] Antibody

CAT: 0013-GTR18336213-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18336213-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Product Name Alternative
Mixed lineage kinase domain-like protein; hMLKL
UniProt
Q8NB16
Reactivity
Human
Immunogen
A synthesized peptide derived from human MLKL
Clonality
Monoclonal
Conjugation
Unconjugated
Purification
Affinity-chromatography
Dilution
WB 1:500~1:2000 IHC 50~200
Form
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
IHC, WB
Host or Source
Rabbit
Isotype
Rabbit IgG

UniProtKB · Q8NB16

Mixed lineage kinase domain-like protein

MLKL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NB16
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MLKL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hMLKL
EC number
—
Processing
—
Secondary accessions
A6NCE4, Q8N6V0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmMembraneNucleus

Domain

Coiled coil

Biological process

Necrosis

PTM

Phosphoprotein

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