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IKK alpha Rabbit mAb [KD Validated] Antibody

CAT: 0013-GTR18335422-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18335422-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation.
Product Name Alternative
CHUK; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; IkappaB kinase; IkB kinase alpha subunit; IkBKA; IKK-A; IKK-a kinase; IKK-alpha; IKK1; IKKA
UniProt
O15111
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human IKK alpha
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Signal Transduction
Purification
Affinity-chromatography
Dilution
WB 1:5000~1:20000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50
Form
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
FC, ICC, IHC, IP, WB
Host or Source
Rabbit
Isotype
Rabbit IgG

UniProtKB · O15111

Inhibitor of nuclear factor kappa-B kinase subunit alpha

IKKA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15111
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CHUK
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
I-kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase
EC number
2.7.11.10
Processing
—
Secondary accessions
O14666, Q13132, Q5W0I4, Q92467
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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