Bergamottin

• Description:

  Bergamottin is a potent and competitive CYP1A1 inhibitor with a Ki of 10.703 nM.

• Product Name Alternative:

  5-Geranoxypsoralen; Bergamotine; Bergaptin

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  Cytochrome P450

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Bergamottin.html

• Purity:

  99.94

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1C=CC2=C(OC/C=C(C)/CC/C=C(C)/C)C3=C(OC=C3)C=C2O1

• Molecular Formula:

  C21H22O4

• Molecular Weight:

  338.40

• Precautions:

  H315, H319

• References & Citations:

  [1]Olguín-Reyes S, et al. Bergamottin is a competitive inhibitor of CYP1A1 and is antimutagenic in the Ames test. Food Chem Toxicol. 2012 Sep;50 (9) :3094-9.|[2]Wu HJ, et al. Bergamottin isolated from Citrus bergamia exerts in vitro and in vivo antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and invasion. Oncol Rep. 2016 Jul;36 (1) :324-32.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  CYP1; CYP2

• CAS Number:

  [7380-40-7]