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Angstrom6

CAT: 0804-HY-P2230-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2230-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling[1][2].
CAS Number
220334-14-5
Product Name Alternative
A6 Peptide
UNSPSC
12352209
Target
PAI-1
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/angstrom6.html
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=C(N(CCC1)[C@@H]1C(N[C@@H](CCC(O)=O)C(N[C@H](C(N)=O)CCC(O)=O)=O)=O)[C@H](CCC2)N2C([C@H](CO)NC([C@H](CO)NC([C@H](CCC3)N3C([C@@H](NC(C)=O)CCCCN)=O)=O)=O)=O
Molecular Formula
C39H62N10O15
Molecular Weight
910.97
References & Citations
[1]Ghamande SA, et al. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol. 2008;111 (1) :89-94.|[2]Finlayson M. Modulation of CD44 Activity by A6-Peptide. Front Immunol. 2015;6:135. Published 2015 Mar 30.|[3]Piotrowicz RS, et al. A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells. Mol Cancer Ther. 2011;10 (11) :2072-2082.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Alternative Products

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MBS3847311-01Angstrom6
A22731-500Angstrom6 500mg
A22731-25Angstrom6 25mg
A22731-10Angstrom6 10mg
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A22731-100Angstrom6 100mg
A22731-50Angstrom6 50mg
A22731-5Angstrom6 5mg

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