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Amcinonide (Standard)

CAT: 0804-HY-B1197RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1197RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amcinonide (Standard) is the analytical standard of Amcinonide. This product is intended for research and analytical applications. Amcinonide is an inhibitor of NO release (IC50 = 3.38 nM) . Amcinonide inhibits NNC-induced expression of the proinflammatory genes iNOS, TNF-α, and IL-1β in glial cells. Amcinonide reduces the numbers of T6+/Ia+ cells with a concomitant increase in T6+/Ia- cells. Amcinonide induces a selective reduction in expression of Ia antigens. Amcinonide can also be studied in research for eczematous dermatitis[1][2][3].
CAS Number
51022-69-6
Product Name Alternative
CL-34699 (Standard)
UNSPSC
12352005
Target
Glucocorticoid Receptor; Interleukin Related; NO Synthase; Reference Standards; TNF Receptor
Type
Reference Standards
Related Pathways
Apoptosis; Immunology/Inflammation; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/amcinonide-standard.html
Smiles
C[C@@]12[C@@]3(C(COC(C)=O)=O)[C@@](OC4(O3)CCCC4)([H])C[C@@]1([H])[C@]5([H])CCC6=CC(C=C[C@]6(C)[C@@]5(F)[C@@H](O)C2)=O
Molecular Formula
C28H35FO7
Molecular Weight
502.57
References & Citations
[1]Hong J, et al. Identification and characterization of triamcinolone acetonide, a microglial-activation inhibitor. Immunopharmacol Immunotoxicol. 2012 Dec;34 (6) :912-918.|[2]Berman B, et al. Modulation of expression of epidermal Langerhans cell properties following in situ exposure to glucocorticosteroids. J Invest Dermatol. 1983 Mar;80 (3) :168-171.|[3]Bickers D. R. (1984) . A comparative study of amcinonide and halcinonide in the treatment of eczematous dermatitis. Cutis, 34 (2), 190–194.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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