Pepstatin A

Pepstatin A Catalog number: MDP0763 CAS Number: N/A Sequence: Isovaleryl-L-valyl-L-valyl[(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl]-L-alanyl[(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid] Amount: 10 mg Molecular Weight: 685.6 g/mol Supplied as: Powder Applications: molecular tool for various biochemical applications Storage: -20 °C WARNING: For in vitro Research Use Only. NOT for use on humans or animals. Grade: Biotechnology grade. All products are highly pure. References: 1: Mothes E, Shoeman RL, Traub P. Pepstatin A: polymerization of an oligopeptide Micron. 1994;25(2):189-217. 2: Purushothaman K, Bhat SK, Siddappa S, Singh SA, Subbaiah R, Marathe GK, Rao G Appu Rao A. Aspartic protease-pepstatin A interactions: Structural insights on the thermal inactivation mechanism Biochimie. 2021 Oct;189:26-39. 3: Matúz K, Mótyán J, Li M, Wlodawer A, Tőzsér J. Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin FEBS J. 2012 Sep;279(17):3276-86. 4: Du C, Wang J, Liu X, Li H, Geng D, Yu L, Chen Y, Zhang J. Construction of Pepstatin A-Conjugated ultrasmall SPIONs for targeted positive MR imaging of epilepsy-overexpressed P-glycoprotein Biomaterials. 2020 Feb;230:119581. 5: Maurer A, Kalbacher H. Pepstatin pull-down at high pH is a powerful tool for detection and analysis of napsin A Biochem Biophys Res Commun. 2019 Jul 12;515(1):145-148. 6: Yu X, Wang J, Liu J, Shen S, Cao Z, Pan J, Zhou S, Pang Z, Geng D, Zhang J. A multimodal Pepstatin A peptide-based nanoagent for the molecular imaging of P-glycoprotein in the brains of epilepsy rats Biomaterials. 2016 Jan;76:173-86. 7: Aoki W, Kitahara N, Miura N, Morisaka H, Yamamoto Y, Kuroda K, Ueda M. Candida albicans possesses Sap7 as a pepstatin A-insensitive secreted aspartic protease PLoS One. 2012;7(2):e32513. 8: Yoshida H, Okamoto K, Iwamoto T, Sakai E, Kanaoka K, Hu JP, Shibata M, Hotokezaka H, Nishishita K, Mizuno A, Kato Y. Pepstatin A, an aspartic proteinase inhibitor, suppresses RANKL-induced osteoclast differentiation J Biochem. 2006 Mar;139(3):583-90. 9: Sangenito LS, Gonçalves KC, Abi-Chacra EA, Sodré CL, d'Avila-Levy CM, Branquinha MH, Santos AL. Multiple effects of pepstatin A on Trypanosoma cruzi epimastigote forms Parasitol Res. 2012 Jun;110(6):2533-40. 10: Okada M, Irie S, Sawada M, Urae R, Urae A, Iwata N, Ozaki N, Akazawa K, Nakanishi H. Pepstatin A induces extracellular acidification distinct from aspartic protease inhibition in microglial cell lines Glia. 2003 Aug;43(2):167-74.
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Catalog Number: MDP0763 (10 mg)

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