Protegrin-1

• Description:

  Protegrin-1 is an orally active antibacterial peptide. Protegrin-1 activates ERK, COX2, NFκB, inhibits Apoptosis, and NO production. Protegrin-1 has antibacterial activity against S. aureus, E. faecium, E. coli, P. aeruginosa and K. Pneumoniae, with MBC values between 10 and 20 µM. Protegrin-1 has antiviral activity against dengue NS2B-NS3. Protegrin-1 has anti-inflammatory activity. Protegrin-1 is used in the study of inflammatory diseases and infections[1][2][3][4][5][6][7][8].

• Product Name Alternative:

  PG1

• UNSPSC:

  12352209

• Target:

  Apoptosis; Bacterial; COX; Dengue Virus; ERK; NF-κB; NO Synthase

• Type:

  Peptides

• Related Pathways:

  Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/protegrin-1.html

• Purity:

  99.55

• Solubility:

  DMSO : 20 mg/mL (ultrasonic)

• Smiles:

  O=C(N[C@]1([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N2)=O)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC(CNC(CNC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)C(N[C@@H](C(C)C)C(NCC(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)C(C)C)=O)([H])CSSC1)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)[C@@H]2CC4=CC=C(C=C4)O

• Molecular Formula:

  C88H147N37O19S4

• Molecular Weight:

  2155.61

• References & Citations:

  [1]Rothan HA, et al. Protegrin-1 inhibits dengue NS2B-NS3 serine protease and viral replication in MK2 cells. J Biomed Biotechnol. 2012;2012:251482.|[2]Penney J, et al. Protegrin 1 Enhances Innate Cellular Defense via the Insulin-Like Growth Factor 1 Receptor Pathway. Front Cell Infect Microbiol. 2018 Sep 28;8:331.|[3]Soundrarajan N, et al. Protegrin-1 cytotoxicity towards mammalian cells positively correlates with the magnitude of conformational changes of the unfolded form upon cell interaction. Sci Rep. 2019 Aug 9;9 (1) :11569. |[4]Tu Y, et al. Effect of astragalus and astragalus polysaccharide on antimicrobial peptides PR-39 and protegrin-1 gene expression in pigs. Turkish Journal of Veterinary & Animal Sciences, 2006, 30 (3) : 325-330.|[5]Li X, et al. Protegrin-1 inhibits porcine ovarian granulosa cell apoptosis from H2O2-induced oxidative stress via the PERK/eIF2α/CHOP signaling pathway in vitro. Theriogenology. 2022 Feb;179:117-127.|[6]Javed A, et al. Antimicrobial and immunomodulatory activities of porcine cathelicidin Protegrin-1. Mol Immunol. 2024 Sep;173:100-109.|[7]Steinberg DA, et al. Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity. Antimicrob Agents Chemother. 1997 Aug;41 (8) :1738-42.|[8]Osakowicz C, et al. Protective and Anti-Inflammatory Effects of Protegrin-1 on Citrobacter rodentium Intestinal Infection in Mice. Int J Mol Sci. 2021 Aug 31;22 (17) :9494.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [168831-77-4]