Hydroxyzine (pamoate)

• UNSPSC Description:

  Hydroxyzine pamoate is a histamine receptor H1 antagonist, one of the salt forms of Hydroxyzine, soluble in dimethyl formamide and chloroform but insoluble in water and alcohol[1].

• Target Antigen:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/Hydroxyzine-pamoate.html

• Purity:

  99.85

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C(O)C(CC2=C3C=CC=CC3=CC(C(O)=O)=C2O)=C4C=CC=CC4=C1)O.ClC5=CC=C(C(N6CCN(CCOCCO)CC6)C7=CC=CC=C7)C=C5

• Molecular Weight:

  763.27

• References & Citations:

  [1]C T King, et al. Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. Am J Obstet Gynecol. 1966 May 1;95(1):109-11.|[2]Tadiboyina Sirisha, et al. Enantioselective UFLC Determination of Hydroxyzine Enantiomers and Application to a Pharmacokinetic Study in Rabbits. J Chromatogr Sci. 2016 Nov;54(10):1806-1812.|[3]Loyd V, et al. Hydroxyzine Pamoate 5 mg/mL Oral Suspension. US Pharm. 2014;39(5):57-58.|[4]Petra Bizikova, et al. Blackwell Publishing Ltd Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of hydroxyzine to healthy dogs. Vet Dermatol. 1966 May 1;95(1):109-11.|[5]J L Barbet, et al. Duration of inhibition of immediate skin test reactivity by hydroxyzine hydrochloride in dogs. J Am Vet Med Assoc. 1989 Jun 1;194(11):1565-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  10246-75-0