Sofosbuvir (Standard)

Sofosbuvir (Standard)

• CAS Number: 1190307-88-0
• UNSPSC Description: Sofosbuvir (Standard) is the analytical standard of Sofosbuvir. This product is intended for research and analytical applications. Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM[1].
• Target Antigen: HCV
• Type: Reference Standards
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sofosbuvir-standard.html
• Smiles: C[C@@]1(F)[C@H](O)[C@@H](CO[P@](OC2=CC=CC=C2)(N[C@@H](C)C(OC(C)C)=O)=O)O[C@H]1N(C=CC(N3)=O)C3=O
• Molecular Weight: 529.45
• References & Citations: [1]Murakami E, et al.
 Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.J Biol Chem. 2010 Nov 5;285(45):34337-47.|[2]Lam AM, et al.
 Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.
 Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68.|[3]Sofia MJ, et al. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem. 2010 Oct 14;53(19):7202-18.|[4]Zhang X, et al. Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism. Eur J Med Chem. 2018 Jan 1;143:1053-1065.
• Shipping Conditions: Room temperature