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Omidenepag

CAT: 0804-HY-17642-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17642-01Size:5 mg
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Description
Omidenepag (UR-7276), a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC50 of 1.1 nM. Omidenepag shows binding affinities (IC50) 10 nM for h-EP2. Omidenepag is used in research on diseases related to intraocular pressure[1][2].
CAS Number
1187451-41-7
Product Name Alternative
UR-7276
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/omidenepag.html
Concentration
10mM
Purity
99.86
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)CNC1=NC(CN(CC2=CC=C(N3N=CC=C3)C=C2)S(=O)(C4=CC=CN=C4)=O)=CC=C1
Molecular Formula
C23H22N6O4S
Molecular Weight
478.52
References & Citations
[1]Iwamura R, et al. Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl. J Med Chem. 2018 Aug 9;61 (15) :6869-6891.|[2]Nakamura N, et al. Effects of selective EP2 receptor agonist, omidenepag, on trabecular meshwork cells, Schlemm's canal endothelial cells and ciliary muscle contraction. Sci Rep. 2021 Aug 10;11 (1) :16257.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP

Alternative Products

CatalogName
BA5700-5Omidenepag
MXB45119-01Omidenepag isopropyl

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