DBCO-PEG4-GGFG-Dxd

DBCO-PEG4-GGFG-Dxd

• CAS Number: 2694856-51-2
• UNSPSC Description: DBCO-PEG4-GGFG-Dxd is a agent-linker conjugate for ADC with potent antitumor activity by using Dxd (a DNA topoisomerase I inhibitor), linked via the cleavable ADC linker DBCO-PEG4-GGFG[1]. DBCO-PEG4-GGFG-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
• Target Antigen: Drug-Linker Conjugates for ADC
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dbco-peg4-ggfg-dxd.html
• Smiles: O=C1OCC2=C(C=C(C3=NC4=CC(F)=C(C)C(CC[C@@H]5NC(COCNC(CNC([C@H](CC6=CC=CC=C6)NC(CNC(CNC(CCOCCOCCOCCOCCNC(CCC(N7C8=CC=CC=C8C#CC9=CC=CC=C9C7)=O)=O)=O)=O)=O)=O)=O)=O)=C4C5=C3C%10)N%10C2=O)[C@]1(CC)O
• Molecular Weight: 1375.45
• References & Citations: [1]Anish Thomas, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016 Jun;17(6):e254-e262.
• Shipping Conditions: Blue Ice