Anti-Sarcomeric Actinin Alpha 2 / ACTN2(ACTN2/3291)

Anti-Sarcomeric Actinin Alpha 2 / ACTN2(ACTN2/3291)

• Description: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms: Actin binding protein; Alpha actinin skeletal muscle; isoform 2; CMD1AA; F-actin cross-linking protein
• CAS Number: 9007-83-4
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name: ACTN2
• Gene ID: 88
• NCBI Gene ID: 498178
• UniProt: P35609
• Cellular Locus: Cytoskeleton
• Host: Mouse
• Species Reactivity: Human
• Immunogen: A recombinantfragment (aa557-692) ofhuman ACTN2 protein(exact sequence is proprietary)
• Target Antigen: ACTN2 | Sarcomeric Actinin Alpha 2
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Clone: ACTN2/3291
• Conjugation: Purified, with BSA
• Source: Animal
• Applications: IHC, FFPE (verified)
• Validated Applications: IHC, FFPE
• Positive Control: Skeletal orCardiac Muscle.
• Concentration: 0.2 mg/mL
• Buffer: PBS, 0.05% BSA, 0.05% azide
• Molecular Weight: 103 kDa
• Shipping Conditions: Room temperature
• Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years