Anti-MUC4 (Mucin 4 / Gastric Mucin)(MUC4/3105)

Anti-MUC4 (Mucin 4 / Gastric Mucin)(MUC4/3105)

• Description: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100%) and sensitive (90%) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms: Ascites sialoglycoprotein 1; Ascites sialoglycoprotein 2; Ascites sialoglycoprotein; ASGP; ASGP-1; ASGP-2; Mucin 4 cell surface associated; Mucin-4 beta chain; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin
• CAS Number: 9007-83-4
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name: MUC4
• Gene ID: 4585
• NCBI Gene ID: 369646
• UniProt: Q99102
• Cellular Locus: Plasma membrane
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Recombinant fragment (around aa 1730-1864) of human MUC4 protein (exact sequence is proprietary)
• Target Antigen: MUC4
• Clonality: Monoclonal
• Isotype: IgG2b κ
• Clone: MUC4/3105
• Conjugation: Purified, BSA-free
• Source: Animal
• Applications: IHC, FFPE (verified)
• Validated Applications: IHC, FFPE
• Field of Research: Cancer, Mucins
• Positive Control: Stomach, Colon or esophagus.
• Concentration: 1 mg/mL
• Buffer: PBS, no BSA, no azide
• Molecular Weight: 235 kDa
• Shipping Conditions: Room temperature
• Storage Conditions: -35°C to -5°C ; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years