Anti-C1QB / Complement C1q B-Chain(C1QB/2961), CF640R conjugate
CAT:
37-BNC402961-500
Size:
500 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-C1QB / Complement C1q B-Chain(C1QB/2961), CF640R conjugate
- Description: Complement C1q B Chain (C1qb) is a subunit of C1q. C1q is composed of 6 polypeptide chains each of C1qa, C1qb, and C1qc. C1q is a component of the classical complement pathway, and thereby plays an important role in the immune response. Each C1q subunit contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Synonyms: C1QB; Complement component 1 q subcomponent B chain; Complement component C1q B chain
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: C1QB
- Gene ID: 713
- NCBI Gene ID: 8986
- UniProt: P02746
- Cellular Locus: Secreted (extracellular)
- Host: Mouse
- Species Reactivity: Human
- Immunogen: Recombinant fragment (around aa 41-188) of human C1QB protein (exact sequence is proprietary)
- Target Antigen: C1QB | Complement C1q B-Chain
- Clonality: Monoclonal
- Isotype: IgG1 κ
- Clone: C1QB/2961
- Conjugation: CF640R
- Source: Animal
- Applications: IHC, FFPE (verified)
- Validated Applications: IHC, FFPE
- Field of Research: Immunology
- Positive Control: Human liver, kidney or brain tissue (IHC).
- Concentration: 0.1 mg/mL
- Buffer: PBS, 0.1% BSA, 0.05% azide
- Molecular Weight: 26-29 kDa
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years