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Tal1 (BTL73), 0.2mg/mL

CAT: 0037-BNUB2852-500Size: 1x 500 µLDry Ice: NoHazardous: No
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CAT#:0037-BNUB2852-500Size:1x 500 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
BHLHa17; Class A basic helix-loop-helix protein 17; OTTHUMP00000009563; OTTHUMP00000009564; SCL; STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR; Stem cell protein; T cell acute lymphocytic leukemia 1; T cell acute lymphocytic leukemia 1 protein; T cell acute lymphocytic leukemia 1 protein; T cell leukemia/lymphoma 5 protein; T-cell acute lymphocytic leukemia protein 1; T-cell leukemia/lymphoma protein 5; Tal 1 product; TAL 1 protein; TAL bHLH transcription factor 1 erythroid differentiation factor; TAL-1
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
TAL1
Gene ID
6886
NCBI Gene ID
705618
UniProt
P17542
Swiss Prot
P17542
Host
Mouse
Species Reactivity
Human
Reactivity
Tal1
Immunogen
Recombinant human full-length TAL1 protein
Target Antigen
Tal1
Clonality
Monoclonal
Clone
BTL73
Type
Primary
Source
Animal
Origin
Animal
Applications
CHiP (published) |Flow, intracellular (published) |IHC (published) |IHC, FFPE (published) |EMSA (published)
Positive Control
A549 xenograft.
Stability
2 years
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
42 kDa
References & Citations
Note: References for this clone sold by other suppliers may be listed for expected applications. EMBO J (1997) 16:3145-3157. (WB) Br J Haematol (1998) 102: 449-457. (Flow; IHC) Blood (2002) 100(2): 491-500. (WB; IHC, FFPE; EMSA) Oncogene (2011) 30: 1252-1260. (CHiP)
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG1, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate
Purified, with BSA

UniProtKB · P17542

T-cell acute lymphocytic leukemia protein 1

TAL1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17542
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TAL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TAL-1
EC number
—
Processing
—
Secondary accessions
D3DQ24
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Molecular function

Developmental proteinDNA-binding

Biological process

DifferentiationTranscriptionTranscription regulation

Cellular component

Nucleus

PTM

PhosphoproteinUbl conjugation

Disease

Proto-oncogene
Product Datasheet
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NBP3-07625-100ugMouse Monoclonal SCL/Tal1 Antibody (BTL73)
TA353479LMouse monoclonal Anti-TAL1 Clone BTL73
36-3226-100Anti-Tal1 Monoclonal Antibody (Clone: BTL73)
NBP3-08616APCMouse Monoclonal SCL/Tal1 Antibody (BTL73) [Allophycocyanin]
NBP3-08616PCPMouse Monoclonal SCL/Tal1 Antibody (BTL73) [PerCP]
NBP3-08616HMouse Monoclonal SCL/Tal1 Antibody (BTL73) [HRP]
NBP3-08616PEMouse Monoclonal SCL/Tal1 Antibody (BTL73) [PE]
NBP3-08616FMouse Monoclonal SCL/Tal1 Antibody (BTL73) [FITC]
NBP3-08616BMouse Monoclonal SCL/Tal1 Antibody (BTL73) [Biotin]
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