Hydroxyflutamide (Standard)

• Description :

  Hydroxyflutamide (Standard) (HFT (Standard) ) is the analytical standard of Hydroxyflutamide (HY-W013272) . This product is intended for research and analytical applications. Hydroxyflutamide (HFT) is the active metabolite of Flutamide (HY-B0022) and exhibits oral activity. Hydroxyflutamide is a potent androgen receptor antagonist with an IC50 of 700 nM. Hydroxyflutamide can affect embryonic development and reproductive tract development in mice. Additionally, Hydroxyflutamide can enhance the efficacy of Bacillus Calmette-Guérin (BCG) to better inhibit the progression of bladder cancer. Hydroxyflutamide can be used in research related to tumors and reproductive diseases[1][2].

• Product Name Alternative :

  HFT (Standard)

• UNSPSC :

  12352005

• Target :

  Akt; Androgen Receptor; Drug Metabolite; Gap Junction Protein; Integrin; PI3K; Reference Standards

• Type :

  Reference Standards

• Related Pathways :

  Cytoskeleton; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hydroxyflutamide-standard.html

• Smiles :

  CC(C)(O)C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)=O

• Molecular Formula :

  C11H11F3N2O4

• Molecular Weight :

  292.21

• References & Citations :

  [1]Furr BJ, et, al. Casodex: preclinical studies and controversies. Ann N Y Acad Sci. 1995 Jun 12;761:79-96. |[2]Liu HL, et, al. A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations. Int J Mol Sci. 2017 Aug 23;18 (9) :1823.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [52806-53-8]