Hydroxyflutamide (Standard)

CAT: 0804-HY-W013272RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W013272RSize:1 Each
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Description
Hydroxyflutamide (Standard) (HFT (Standard) ) is the analytical standard of Hydroxyflutamide (HY-W013272) . This product is intended for research and analytical applications. Hydroxyflutamide (HFT) is the active metabolite of Flutamide (HY-B0022) and exhibits oral activity. Hydroxyflutamide is a potent androgen receptor antagonist with an IC50 of 700 nM. Hydroxyflutamide can affect embryonic development and reproductive tract development in mice. Additionally, Hydroxyflutamide can enhance the efficacy of Bacillus Calmette-Guérin (BCG) to better inhibit the progression of bladder cancer. Hydroxyflutamide can be used in research related to tumors and reproductive diseases[1][2].
CAS Number
[52806-53-8]
Product Name Alternative
HFT (Standard)
UNSPSC
12352005
Target
Akt; Androgen Receptor; Drug Metabolite; Gap Junction Protein; Integrin; PI3K; Reference Standards
Type
Reference Standards
Related Pathways
Cytoskeleton; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hydroxyflutamide-standard.html
Smiles
CC(C)(O)C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)=O
Molecular Formula
C11H11F3N2O4
Molecular Weight
292.21
References & Citations
[1]Furr BJ, et, al. Casodex: preclinical studies and controversies. Ann N Y Acad Sci. 1995 Jun 12;761:79-96. |[2]Liu HL, et, al. A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations. Int J Mol Sci. 2017 Aug 23;18 (9) :1823.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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