Anti-Cytokeratin 13 (Non-Keratinized Squamous Epithelial Marker)(KRT13/2213), CF640R conjugate
CAT:
37-BNC402659-500
Size:
500 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-Cytokeratin 13 (Non-Keratinized Squamous Epithelial Marker)(KRT13/2213), CF640R conjugate
- Description: Cytokeratin 13 (KRT13) is the major acidic keratin, which together with KRT4, its basic partner, is expressed in the suprabasal layers of non-cornified stratified epithelia including tongue mucosa, esophagus, anal canal epithelium, tracheal epithelium, uterine cervix, and urothelium. Defects in the KRT13 gene are a cause of white sponge nevus of cannon (WSN), a rare autosomal dominant disorder, which predominantly affects non-cornified stratified squamous epithelia and is characterized by the presence of soft, white and spongy plaques in the oral mucosa. KRT13 has been used as a marker for non-keratinized squamous epithelium. It is also expressed in various squamous metaplasia, but it is down regulated in squamous dysplasia and squamous carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Synonyms: CK13; Cytokeratin-13; Keratin Type I Cytoskeletal 13; Keratin-13; KRT13; Type I Cytoskeletal 13; WSN2
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: KRT13
- Gene ID: 3860
- NCBI Gene ID: 654550
- UniProt: P13646
- Cellular Locus: Cytoskeleton
- Host: Mouse
- Species Reactivity: Human
- Immunogen: Recombinant full-length human KRT13 protein
- Target Antigen: Cytokeratin 13
- Clonality: Monoclonal
- Isotype: IgG
- Clone: KRT13/2213
- Conjugation: CF640R
- Source: Animal
- Applications: Flow, intracellular (verified) | IHC, FFPE (verified)
- Validated Applications: FC, IHC, FFPE
- Field of Research: Cancer, Cytoskeleton
- Positive Control: HeLa or A431 cells. Skin or Squamous cell carcinoma.
- Concentration: 0.1 mg/mL
- Buffer: PBS, 0.1% BSA, 0.05% azide
- Molecular Weight: 52 kDa
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years