Anti-MTF1(MTF1/2649)
CAT:
37-BNUM2649-50
Size:
50 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-MTF1(MTF1/2649)
- Description: The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Synonyms: Metal regulatory transcription factor 1; Metal response element binding transcription factor 1; Metal responsive transcription factor 1; MRE-binding transcription factor 1; MTF1; Transcription factor MTF1; Zinc regulatory factor (ZRF)
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: MTF1
- Gene ID: 4520
- NCBI Gene ID: 471991
- UniProt: Q14872
- Cellular Locus: Nucleus
- Host: Mouse
- Species Reactivity: Human
- Immunogen: Recombinant full-length human MTF1 protein
- Target Antigen: MTF1
- Clonality: Monoclonal
- Isotype: IgG1 κ
- Clone: MTF1/2649
- Conjugation: Purified, BSA-free
- Source: Animal
- Applications: IHC, FFPE (verified)
- Validated Applications: IHC, FFPE
- Positive Control: Human kidney.
- Concentration: 1 mg/mL
- Buffer: PBS, no BSA, no azide
- Molecular Weight: 70 kDa
- Shipping Conditions: Room temperature
- Storage Conditions: -35°C to -5°C ; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years