Anti-Cyclin A2 (S- & G2-phase Cyclin)(CCNA2/2333), CF647 conjugate
CAT:
37-BNC472333-100
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-Cyclin A2 (S- & G2-phase Cyclin)(CCNA2/2333), CF647 conjugate
- Description: Recognizes a protein of 54 kDa, which is identified as cyclin A. Its epitope is located amino acids 144-148 of human Cyclin A2. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdk's) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdk's. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while cyclin B is a critical regulator of mitosis. Mutation or disruption of normal cyclin A expression causes cells to arrest in G2-phase. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Synonyms: CCN1; CCNA; CCNA2; Cyclin A2
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: CCNA2
- Gene ID: 890
- NCBI Gene ID: 58974
- UniProt: P20248
- Cellular Locus: Nucleus & cytoplasm
- Host: Mouse
- Species Reactivity: Human
- Immunogen: Full length recombinant Cyclin A2 protein
- Target Antigen: Cyclin A2
- Clonality: Monoclonal
- Isotype: IgG2a κ
- Clone: CCNA2/2333
- Conjugation: CF647
- Source: Animal
- Applications: IHC, FFPE (verified)
- Validated Applications: IHC, FFPE
- Positive Control: K-562 and HeLa cells; Tonsil.
- Concentration: 0.1 mg/mL
- Buffer: PBS, 0.1% BSA, 0.05% azide
- Molecular Weight: 54 kDa
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years