Anti-Transthyretin (Prealbumin)(CPTC-TTR-1), Biotin conjugate

• Description:

  Prealbumin, also designated transthyretin, is a major thyroid-hormone binding protein involved in transporting thyroxine from the bloodstream to the brain. Prealbumin is located in the cytoplasm and in the vesicles of developing rat brain cells, and is thought to be transported there from the cerebrospinal fluid via endocytosis. Sequence variants of this protein have been identified in amyloid fibrils from patients with familial amyloidotic polyneuropathy (FAP), the most common form of hereditary systemic amyloidosis. Although the biologically active form of Prealbumin is a tetramer, the amyloidogenic intermediate is thought to be a monomeric species. Prealbumin also binds to the retinol carrier protein RBP (retinol-binding protein). Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  Transthyretin; PALB; HsT2651; prealbumin; amyloidosis type 1; ATTR; TBPA; CTS; CTS1; carpal tunnel syndrome 1; thyroxine-binding prealbumin; prealbumin; HEL111; TTR protein; Epididymis luminal protein 111; prealbumin thyroxine binding; senile systemic amyloidosis antibody

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  TTR

• Gene ID:

  7276

• NCBI Gene ID:

  427202

• UniProt:

  P02766

• Cellular Locus:

  Secreted (extracellular)

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  Recombinant human full-length protein

• Target Antigen:

  Transthyretin

• Clonality:

  Monoclonal

• Isotype:

  IgG2a κ

• Clone:

  CPTC-TTR-1

• Conjugation:

  Biotin

• Source:

  Animal

• Applications:

  WB (verified)

• Validated Applications:

  WB

• Positive Control:

  HepG2, Pancreas and liver.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% BSA, 0.05% azide

• Molecular Weight:

  15 kDa

• Additionnal Information:

  ELISA: For coating, order Ab without BSA; Western blot 1-2 ug/mL; Optimal dilution for a specific application should be determined.|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years

• CAS Number:

  9007-83-4