Anti-14-3-3E / Tryptophan 5-Monooxygenase(CPTC-YWHAE-1), CF568 conjugate

• Description:

  14-3-3E is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. The YWHAE gene which encodes 14-3-3E has also been identified as a possible susceptibility gene for schizophrenia. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  YWHAE; Tyrosine 3-Monooxygenase Activation Protein Epsilon; Tryptophan 5-Monooxygenase Activation Protein Epsilon; epididymis luminal protein 2; Mitochondrial import stimulation factor L subunit; protein kinase C inhibitor protein-1

• CAS Number:

  9007-83-4

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  YWHAE

• Gene ID:

  7531

• NCBI Gene ID:

  513851

• UniProt:

  P62268

• Cellular Locus:

  Cytoplasmic

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  Recombinant human full-length YWHAE protein

• Target Antigen:

  14-3-3E

• Clonality:

  Monoclonal

• Isotype:

  IgG2a κ

• Clone:

  CPTC-YWHAE-1

• Conjugation:

  CF568

• Source:

  Animal

• Applications:

  IHC, FFPE (verified) | WB (verified)

• Validated Applications:

  IHC, FFPE, WB

• Positive Control:

  HEK-293 or A-431 cell lines.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% BSA, 0.05% azide

• Molecular Weight:

  29.4 kDa

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years