Anti-FOLH1 / PSMA (Prostate Epithelial Marker)(FOLH1/2121)

• Description:

  Folate hydrolase 1 (FOLH1), also known as Prostate-specific membrane antigen (PSMA), is a type II transmembrane glycoprotein belonging to the M28 peptidase family. FOLH1 has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  Cell growth-inhibiting gene 27 protein (GIG27); Folylpoly-gamma-glutamate carboxypeptidase (FGCP); Glutamate carboxylase II (GCPII); N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1 or NAALADase); Prostate-specific membrane antigen (PSM or PSMA); Pteroylpoly-gamma-glutamate carboxypeptidase

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  FOLH1

• Gene ID:

  2346

• NCBI Gene ID:

  654487

• UniProt:

  Q04609

• Cellular Locus:

  Plasma membrane

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  Recombinant human FOLH1 protein fragment (around aa 232-433) (exact sequence is proprietary)

• Target Antigen:

  FOLH1 | PSMA

• Clonality:

  Monoclonal

• Isotype:

  IgG2b κ

• Clone:

  FOLH1/2121

• Conjugation:

  Purified, with BSA

• Disease:

  Tumor

• Source:

  Animal

• Positive Control:

  LNCap or HepG2 cells. Prostate Carcinoma.

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS, 0.05% BSA, 0.05% azide

• Molecular Weight:

  100 kDa

• Additionnal Information:

  For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years

• CAS Number:

  9007-83-4