Anti-CD3e, Mouse(145-2C11), CF640R conjugate

• Description:

  CD3 chains. CD3 plays a critical role in TCR signal transduction, T-cell activation, and antigen recognition by binding the peptide/MHC antigen complex. The 145-2C11 antibody is useful for in vitro blocking and activation assays, as well as apoptosis induction and in vivo T-cell depletion._x000D_ _x000D_ Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_

• Synonyms:

  CD3 epsilon; CD3e; CD3e antigen epsilon polypeptide (TiT3 complex); CD3e molecule; epsilon (CD3-TCR complex); IMD18; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3E; TCRE

• CAS Number:

  9007-83-4

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  Cd3e (Mouse)

• Gene ID:

  12501

• NCBI Gene ID:

  210361

• UniProt:

  P22646

• Cellular Locus:

  Plasma membrane

• Host:

  Armenian Hamster

• Species Reactivity:

  Mouse

• Immunogen:

  H2Kb specific Mouse cytotoxic T lymphocyte clone BM10 37

• Target Antigen:

  CD3e

• Clonality:

  Monoclonal

• Isotype:

  IgG κ

• Clone:

  145-2C11

• Conjugation:

  CF640R

• Disease:

  Tumor

• Source:

  Animal

• Applications:

  Flow, surface (published) | Functional studies (published) | IP (published)

• Validated Applications:

  FC, IP, Functional assays

• Positive Control:

  MPBMC's or Thymus or Lymph Node.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% BSA, 0.05% azide

• Molecular Weight:

  23 kDa

• References & Citations:

  Note: References for this clone sold by other suppliers may be listed for expected applications. PNAS USA (1987) 84:1374-1378. (Flow, IP) Eur J Immunol (1990) 20: 509-515. (functional studies) J Immunol (2003) 171:2496-2503. (Flow; IP; functional studies)

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years