CD40, Mouse (FGK45.5), 1mg/mL

Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4. 5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

9007-83-4

B cell surface antigen CD40; CD40 type II isoform; p50; Bp50; CD40L receptor; CDW40; TRAP; IMD3; IGM; Tnfrsf5; HIGM1; GP39; T-BAM

41116161

Primary and secondary antibodies for multiple methodology immunostaining detection application

21939

P27512

P27512

CD40

Purified recombinant Mouse CD40 fusion protein

CD40

FGK45.5

Primary

Animal

Animal

Flow, surface (published) |Functional studies (published)

MPBMC's. Spleen, Thymus or Lymph Node.

2 years

1 mg/mL

PBS, no BSA, no azide

48 kDa

Note: References for this clone sold by other suppliers may be listed for expected applications. Eur J Immunol (1999) 29: 2835-2841. (functional studies; Flow, surface)

RT (ND)

Stable at room temperature or 37°C (98°F) for 7 days.

Guaranteed for at least 24 months from date of receipt when stored as recommended

IgG2a, kappa

Rattus norvegicus (laboratory rat)

PBS, no BSA, no sodium azide (CAS 26628-22-8)