Anti-CD40, Mouse(FGK45.5)
CAT:
37-BNUB2005-100
Size:
100 µL
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-CD40, Mouse(FGK45.5)
- Description: Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4. 5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Synonyms: B cell surface antigen CD40; CD40 type II isoform; p50; Bp50; CD40L receptor; CDW40; TRAP; IMD3; IGM; Tnfrsf5; HIGM1; GP39; T-BAM
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene ID: 21939
- UniProt: P27512
- Cellular Locus: Plasma membrane
- Host: Rat
- Species Reactivity: Mouse
- Immunogen: Purified recombinant Mouse CD40 fusion protein
- Target Antigen: CD40
- Clonality: Monoclonal
- Isotype: IgG2a κ
- Clone: FGK45.5
- Conjugation: Purified, with BSA
- Source: Animal
- Applications: Flow, surface (published) | Functional studies (published)
- Validated Applications: FC, Functional assays
- Positive Control: MPBMC's. Spleen, Thymus or Lymph Node.
- Concentration: 0.2 mg/mL
- Buffer: PBS, 0.05% BSA, 0.05% azide
- Molecular Weight: 48 kDa
- References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Eur J Immunol (1999) 29: 2835-2841. (functional studies; Flow, surface)
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years