Anti-CD134, Mouse (OX40)(OX-86), CF640R conjugate

• Description:

  CD134 is a type I integral membrane protein. This receptor is expressed on activated CD4 and CD8 T cells and B cells. The CD134 binds to CD134 ligand (CD252) to provide a costimulatory signal that is independent of CD28. CD134 is involved in coordinating CD4 T cell selection, migration and cytokine differentiation in T helper (Th)1 and Th2 cells. CD134 is also involved in the stimulation of T cells, T dependent humoral response and generation of optimal CD4 T cell responses in vivo and in vitro. CD134 is expressed on activated CD4 T lymphocytes, and its ligand, CD134L, is found preferentially on activated B cells. Engagement of CD134 with its ligand, CD134L, delivers a strong costimulatory signal to effector T cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  CD134; IMD16; Lymphoid activation antigen (ACT35); OX40 cell surface antigen; OX40L receptor; TAX transcriptionally activated glycoprotein 1 receptor; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4); Txgp1l

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene ID:

  22163

• NCBI Gene ID:

  13885

• UniProt:

  P47741

• Cellular Locus:

  Plasma membrane

• Host:

  Rat

• Species Reactivity:

  Mouse

• Immunogen:

  Purified recombinant Mouse OX-40 antigen

• Target Antigen:

  CD134,

• Clonality:

  Monoclonal

• Isotype:

  IgG1 κ

• Clone:

  OX-86

• Conjugation:

  CF640R

• Source:

  Animal

• Applications:

  Flow, surface (published) | Functional studies (published) | IF (published) | WB (published)

• Validated Applications:

  FC, IF, WB

• Positive Control:

  MPBMC's. Spleen, Thymus or Lymph Node.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% BSA, 0.05% azide

• Molecular Weight:

  ~50 kDa

• References & Citations:

  Note: References for this clone sold by other suppliers may be listed for expected applications. J Immunol (2000) 164:2160-2169. (functional studies) Exp Med (2003) 198(5): 737-746. (Flow, surface) Am J Respir Crit Care Med (2010) 181: 688-698. (WB) J Leukoc Biol (2007) 81: 766-774. (IF)

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years

• CAS Number:

  9007-83-4