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Prohibitin (Mitochondrial Marker) (PHB/1881), 0.2mg/mL

CAT: 0037-BNUB1881-500Size: 1x 500 µLDry Ice: NoHazardous: No
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CAT#:0037-BNUB1881-500Size:1x 500 µL
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Description
Recognizes a protein of 30 kDa which is identified as Prohibitin, an evolutionarily conserved protein with homologues found in yeast to man. It is located in the inner membrane of mitochondria. Although prohibitin mRNA and protein expression occurs throughout the cell cycle, maximum levels are detected during the G1/S phase transition and minimum levels are seen in S phase and the G2/mitosis boundary. Prohibitin is located exclusively in the mitochondria with the highest concentration on the inner membrane. Prohibitin is an ideal mitochondrial marker. It shows antiproliferative activity and has been proposed to play a role in normal cell cycle regulation, replicative senescence, cellular immortalization, and tumor suppression. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
Epididymis luminal protein 215; Epididymis secretory sperm binding protein Li 54e; HEL 215; HEL S 54e; PHB; PHB1; Prohibitin
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
PHB
Gene ID
5245
NCBI Gene ID
514303
UniProt
P35232
Swiss Prot
P35232
Host
Mouse
Species Reactivity
Human
Reactivity
Prohibitin
Immunogen
Recombinant human PHB protein fragment (aa167-261) (exact sequence is proprietary)
Target Antigen
Prohibitin
Clonality
Monoclonal
Clone
PHB/1881
Type
Primary
Source
Animal
Origin
Animal
Applications
IHC, FFPE (verified) |WB (verified)
Positive Control
HepG2, A431 or MCF-7, Ramos, Jurkat, K562 cells. Liver, Kidney, Heart or Endometrium.
Stability
2 years
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
~30 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2c, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate
Purified, with BSA

UniProtKB · P35232

Prohibitin 1

PHB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35232
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PHB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DY47, Q4VBQ0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmMembraneMitochondrionMitochondrion inner membraneNucleus

Domain

Coiled coil

Biological process

DNA synthesisHost-virus interaction

Disease

Proto-oncogene
Product Datasheet
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Alternative Products

CatalogName
36-2928-100Anti-Prohibitin (Mitochondrial Marker) Monoclonal Antibody (Clone: PHB/1881)
36-2935-20Anti-Prohibitin (Mitochondrial Marker) Monoclonal Antibody (Clone: PHB/3225)
36-2934-100Anti-Prohibitin (Mitochondrial Marker) Monoclonal Antibody (Clone: PHB/3194)
36-2933-20Anti-Prohibitin (Mitochondrial Marker) Monoclonal Antibody (Clone: PHB/3193)
36-2930-100Anti-Prohibitin (Mitochondrial Marker) Monoclonal Antibody (Clone: PHB/3231)
36-2929-100Anti-Prohibitin (Mitochondrial Marker) Monoclonal Antibody (Clone: PHB/3230)
36-2939-20Anti-Prohibitin (Mitochondrial Marker) Monoclonal Antibody (Clone: PHB/3229)
36-2936-100Anti-Prohibitin (Mitochondrial Marker) Monoclonal Antibody (Clone: PHB/3226)
36-2938-100Anti-Prohibitin (Mitochondrial Marker) Monoclonal Antibody (Clone: PHB/3228)
36-2932-100Anti-Prohibitin (Mitochondrial Marker) Monoclonal Antibody (Clone: PHB/1882)

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