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Gramine

CAT: 0804-HY-N0166-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0166-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively[1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist[2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[1].
CAS Number
87-52-5
Product Name Alternative
Donaxine
UNSPSC
12352005
Hazard Statement
H302+H312
Target
Adiponectin Receptor; Reverse Transcriptase
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Gramine.html
Concentration
10mM
Purity
99.81
Solubility
DMSO : ≥ 125 mg/mL
Smiles
CN(C)CC1=CNC2=C1C=CC=C2
Molecular Formula
C11H14N2
Molecular Weight
174.25
Precautions
H302+H312
References & Citations
[1]Sun Y, et al. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8 (5) :e63354.|[2]Chikazawa M, et al. Identification of Functional Food Factors as β2-Adrenergic Receptor Agonists and Their Potential Roles in Skeletal Muscle. J Nutr Sci Vitaminol (Tokyo) . 2018;64 (1) :68-74.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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