Gramine

• UNSPSC Description:

  Gramine (Donaxine) is a natural alkaloid isolated from giant reed[2], acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively[1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist[2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[1].

• Target Antigen:

  Adiponectin Receptor; Adrenergic Receptor; Reverse Transcriptase

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection; Metabolic Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/Gramine.html

• Purity:

  99.81

• Solubility:

  DMSO : ≥ 125 mg/mL

• Smiles:

  CN(C)CC1=CNC2=C1C=CC=C2

• Molecular Weight:

  174.247

• References & Citations:

  [1]Sun Y, et al. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8(5):e63354.|[2]Chikazawa M, et al. Identification of Functional Food Factors as β2-Adrenergic Receptor Agonists and Their Potential Roles in Skeletal Muscle. J Nutr Sci Vitaminol (Tokyo). 2018;64(1):68-74.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  87-52-5