Gramine

• Description:

  Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively[1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist[2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[1].

• Product Name Alternative:

  Donaxine

• UNSPSC:

  12352005

• Hazard Statement:

  H302+H312

• Target:

  Adiponectin Receptor; Reverse Transcriptase

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection; Metabolic Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/Gramine.html

• Concentration:

  10mM

• Purity:

  99.81

• Solubility:

  DMSO : ≥ 125 mg/mL

• Smiles:

  CN(C)CC1=CNC2=C1C=CC=C2

• Molecular Formula:

  C11H14N2

• Molecular Weight:

  174.25

• Precautions:

  H302+H312

• References & Citations:

  [1]Sun Y, et al. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8 (5) :e63354.|[2]Chikazawa M, et al. Identification of Functional Food Factors as β2-Adrenergic Receptor Agonists and Their Potential Roles in Skeletal Muscle. J Nutr Sci Vitaminol (Tokyo) . 2018;64 (1) :68-74.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [87-52-5]