Anti-CD51 / Integrin V(ITGAV/1610)

Anti-CD51 / Integrin V(ITGAV/1610)

• Description: Integrins are heterodimers composed of noncovalently associated transmembrane both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms: antigen identified by monoclonal antibody L230; CD 51; CD51; DKFZp686A08142; Integrin alpha five; integrin alpha V beta 3; Integrin alpha-5; integrin alpha-V; Integrin alpha-V light chain; integrin alphaVbeta3; integrin; alpha V (vitronectin receptor; alpha polypeptide; antigen CD51); ITAV_HUMAN; ITGAV; MSK 8; Msk8; Vitronectin receptor subunit alpha; VNRA; VTNR
• CAS Number: 9007-83-4
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name: ITGAV
• Gene ID: 3685
• NCBI Gene ID: 436873
• UniProt: P06756
• Cellular Locus: Plasma membrane
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Recombinant human full-length integrin alpha V beta 1 protein
• Target Antigen: CD51 | Integrin V
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Clone: ITGAV/1610
• Conjugation: Purified, BSA-free
• Source: Animal
• Positive Control: Squamous cells, A375M melanoma cells. A549 cells.
• Concentration: 1 mg/mL
• Buffer: PBS, no BSA, no azide
• Molecular Weight: 150-160 kDa under non-reducing conditions. Under reducing conditions, it is cleaved into 2 bands of about 125-130 kDa 20-25 kDa.
• Additionnal Information: For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry
• Shipping Conditions: Room temperature
• Storage Conditions: -35°C to -5°C ; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years