Anti-CD1c(CD1C/1603), CF405S conjugate

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Anti-CD1c(CD1C/1603), CF405S conjugate

CAT:

37-BNC041603-500

Size:

500 µL

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Anti-CD1c(CD1C/1603), CF405S conjugate

Description: The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with -2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23. 1Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Synonyms: BDCA1; CD1; CD1A; CD1c; CD1C antigen c polypeptide; CD1c molecule; Cortical thymocyte antigen CD1C; Differentiation antigen CD1 alpha 3; R7; T cell surface glycoprotein CD1c
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CD1C
Gene ID: 911
NCBI Gene ID: 132448
UniProt: P29017
Cellular Locus: Plasma membrane
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant full-length human CD1c protein
Target Antigen: CD1c
Clonality: Monoclonal
Isotype: IgG1 κ
Clone: CD1C/1603
Conjugation: CF405S
Source: Animal
Positive Control: Expressed on cortical thymocytes, on certain T-cell leukemias and in various other tissues.
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 43 kDa
Additionnal Information: For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry
Shipping Conditions: Room temperature
Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: 2 years

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