Anti-VEGF-R2 / CD309 / Flk-1 / KDR3(DC101), CF405S conjugate

Anti-VEGF-R2 / CD309 / Flk-1 / KDR3(DC101), CF405S conjugate

• Description: This MAb is specific to Mouse VEGFR2/FLK-1/CD309 and does not cross-react with FLK-2. VEGFR2 is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Endothelial cells, embryonic tissues, and megakaryocytes mainly express VEGFR2. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms: CD309; Fetal liver kinase 1 (FLK-1); KDR; Kinase insert domain receptor (a type III receptor tyrosine kinase); KRD1; Ly73; Protein tyrosine kinase receptor FLK1; Vascular endothelial growth factor receptor 2
• CAS Number: 9007-83-4
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name: Kdr (Mouse)
• Gene ID: 16542
• NCBI Gene ID: 285
• UniProt: 35918
• Cellular Locus: Plasma membrane
• Host: Rat
• Species Reactivity: Mouse
• Immunogen: Recombinant full-length Mouse VEGFR2 protein
• Target Antigen: CD309 | Flk-1 | KDR3 | VEGF-R2
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Clone: DC101
• Conjugation: CF405S
• Source: Animal
• Applications: Flow, surface (published) | Functional studies (published) | IHC, frozen (published)
• Validated Applications: FC, IHC,
• Positive Control: Mouse epidermoid, renal cell carcinoma, pancreatic or glioblastoma cells.
• Concentration: 0.1 mg/mL
• Buffer: PBS, 0.1% BSA, 0.05% azide
• Molecular Weight: 180-190 kDa
• References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Cancer Metastasis Rev (1998) 17(2):155-61. (functional studies) J Exp Med (2001) 193(9): 1005-1014. (Flow) FASEB J (2005) 19(14): 2005-2007. (IHC, frozen)
• Shipping Conditions: Room temperature
• Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years