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MS7

CAT: 0804-HY-159009Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159009Size:1 Each
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Description
MS7 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) . NAMPT is overexpressed in many cancer cells to meet the continuous replenishment of NAD+ required for rapid proliferation. MS7, as a NAMPT target protein ligand, can be used to synthesize PROTAC A7, which is an effective NAMPT degrader. MS7 can be used in cancer research[1].
CAS Number
1593654-46-6
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms7.html
Smiles
O=S(C1=CC=C(NC(NCC2=CC=CN=C2)=S)C=C1)(N3CCN(CC3)CC4=CC=CC=C4)=O
Molecular Formula
C24H27N5O2S2
Molecular Weight
481.63
References & Citations
[1]Wu Y, et al. NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion[J]. Acta Pharmaceutica Sinica B, 2022, 12 (6) : 2859-2868.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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