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Flurochloridone

CAT: 0804-HY-121337-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121337-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells[1][2].
CAS Number
61213-25-0
Product Name Alternative
R-40244
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/flurochloridone.html
Purity
99.61
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=C1N(CC(C1Cl)CCl)C2=CC=CC(C(F)(F)F)=C2
Molecular Formula
C12H10Cl2F3NO
Molecular Weight
312.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang F, et al. Flurochloridone Induced Cell Apoptosis via ER Stress and eIF2α-ATF4/ATF6-CHOP-Bim/Bax Signaling Pathways in Mouse TM4 Sertoli Cells. Int J Environ Res Public Health. 2022 Apr 11;19 (8) :4564. |[2]Nikoloff N, et al. Flurochloridone-based herbicides induced genotoxicity effects on Rhinella arenarum tadpoles (Anura: Bufonidae) . Ecotoxicol Environ Saf. 2014 Feb;100:275-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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