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AU1235

CAT: 0804-HY-101867-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101867-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane[1][2].
CAS Number
1338780-86-1
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/AU1235.html
Purity
98.23
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NC(C=CC(F)=C1F)=C1F)NC2(C[C@H](C3)C4)C[C@H]4C[C@H]3C2
Molecular Formula
C17H19F3N2O
Molecular Weight
324.34
References & Citations
[1]McNeil MB, et al. Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors. mSphere. 2020;5 (5) :e00985-20. Published 2020 Oct 14.|[2]Grzegorzewicz AE, et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012;8 (4) :334-341. Published 2012 Feb 19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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