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Ipomoeassin F

CAT: 0804-HY-N10661Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N10661Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs[1][2][3].
CAS Number
915392-44-8
Product Name Alternative
Ipom-F
UNSPSC
12352005
Target
SARS-CoV
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/ipomoeassin-f.html
Solubility
10 mM in DMSO
Smiles
O=C(/C=C/C1=CC=CC=C1)O[C@H]([C@](COC(CCC(CCCCCC2)=O)=O)([H])O[C@](O[C@@]([C@@H](O)[C@H]3OC(C)=O)([H])[C@](O[C@@H]3C)([H])O[C@H]2CCCCC)([H])[C@@H]4O)[C@@H]4OC(/C(C)=C/C)=O
Molecular Formula
C44H62O15
Molecular Weight
830.95
References & Citations
[1]Peristera Roboti, et al.Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis. Sci Rep. 2021 Jun 2;11 (1) :11562.|[2]Shugeng Cao, et al. Ipomoeassin F, a new cytotoxic macrocyclic glycoresin from the leaves of Ipomoea squamosa from the Suriname rainforest.Nat Prod Res. 2007 Aug;21 (10) :872-6.|[3]Sarah O'Keefe, et al. Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor. J Cell Sci. 2021 Feb 19;134 (4) :jcs257758.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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